Hydroethanolic extract of Ixora coccinea leaves inhibits testicular and epididymal toxicity associated with antitumor drug Cisplatin in rats

Cisplatin (Cp) is one of the most effective chemotherapy antineoplastic drugs. Nevertheless, it causes numerous injurious effects on organs, precisely testes. Ixora coccinea (IC) a well-known medicinal herb and has long history use as tonic to promote health. This study revealed inhibitory hydroethanolic extract IC leaves (HEICL) CP-induced testicular damage in male Wistar rats. Thirty (30) adult rats were used divided into six groups five These treated followed: Group 1(control group) 2 administered (0.9% saline) CP (10 mg/kg. b.wt) intraperitoneal (IP) route respectively, 3 4 HEICL at 150 mg/kg 300 5 6 co-treated with Cp + (150 mg/kg) respectively. The treatment duration was 28 days. Spermatological profiles histopathology assessed. Cp-treated showed significant (p<0.05) reduction relative organ weight sperm parameters. On other hand, increased percentage abnormalities control only. results confirmed by histopathological analysis. Contrarily, there modulations cp-induced spermiotoxic following pretreatment. Our research that exerts damaging consequences parameters, tissues, accessory sex organs Pre-treatment for 26 days doses 200 400 bodyweight had protective role against brought CP.